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Minggu, 12 Juni 2011

Lyophilization - An Overview

Lyophilization is more commonly known as freeze-drying. Lyophilization is a process of drying something without damaging its internal structure. It is basically used to dry materials which are sensitive to heat or have delicate structures. Lyophilization is a complex process of drying sensitive things and so it is expensive. The only substance which cannot be preserved by this processs is mammalian cells as they are very fragile.

The biotechnology industry has many methods of preservation but the preferred one is lyophilization. Lyophilization is used to preserve vaccines, pharmaceuticals and other proteins. Freeze-drying is sometimes used to preserve food products thus eliminating the need for refrigeration. The food products dried using such techniques are used by mountain climbers and astronauts. Freeze-dried products are highly absorbent as freeze-drying removes most of the water from them and so adding water can help restore these products to something close to its original state.

Lyophilization process is a complex process. It has a series of steps which should be followed systematically and appropriately. The very basic and first step in this process is to lower the temperature of the substance to its freezing point. The next step is to then insert the substance into a vacuum chamber; this helps the energetic molecules to escape and lowers the temperature even further. The low pressure in the chamber causes the water molecules to be drawn out of the sample. After this step, the condenser attached to the vacuum cleaner converts the airborne moisture into liquid and siphons it away.

While the substance is undergoing this process immense care is taken to ensure that the structure of the substance remains unaltered. Freeze drying is so complex and skillful that it might take about 24 hours to finish the entire process. The final result is a substance whose internal structure is maintained, which can be stored at room temperatures and pressures.

SP Scientific is the synergistic collection of four well-known and highly regarded scientific equipment brands, including VirTis, FTS Systems, Genevac and Hotpack. The joining of these well-established brands as SP Scientific has created one of the largest and most experienced companies in freeze drying (lyophilization), centrifugal evaporation and concentration, temperature control/thermal management, and glassware washers. http://www.spscientific.com/

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